Data from: Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions

Principal Investigator(s):  View help for Principal Investigator(s) US Department of Agriculture; National Agricultural Library

Version:  View help for Version V1

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41598_2017_5860_MOESM1_ESM.csv text/csv 314.9 KB 06/26/2026 08:02:PM
adc_metadata.json application/json 23.5 KB 06/26/2026 11:43:AM
catalog_detail.html text/html 10 KB 06/26/2026 11:43:AM

Project Citation: 

US Department of Agriculture, and National Agricultural Library. Data from: Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2026-06-27. https://doi.org/10.3886/E250347V1

Project Description

Project Title:  View help for Project Title Data from: Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions
Summary:  View help for Summary Chondroitin sulfate (CS) has been widely used for medical and nutraceutical purposes due to its roles in maintaining tissue structural integrity. We investigated if CS disaccharides may act as a bioactive compound and modulate gut microbial composition in mice. Our data show that CS disaccharides supplementation for 16 days significantly reduced blood LPS in the mice experiencing exhaustive exercise stress. CS disaccharides partially restored total fecal short-chain fatty acids from the level significantly repressed in mice under the stress. Our findings demonstrated that CS was likely butyrogenic and resulted in a significant increase in fecal butyrate concentration. CS disaccharides had a profound impact on gut microbial composition, affecting the abundance of 13.6% and 7.3% Operational Taxonomic Units in fecal microbial communities in healthy and stressed mice, respectively. CS disaccharides reduced the prevalence of inflammatory Proteobacteria. Together, our findings demonstrated that CS may ameliorate stress-induced intestinal inflammation. Furthermore, CS significantly increased intestinal Bacteroides acidifaciens population, indirectly exerting its immunomodulatory effect on the intestine. CS disaccharides had a significant impact on a broad range of biological pathways under stressed condition, such as ABC transporters, two-component systems, and carbohydrate metabolism. Our results will facilitate the development of CS as a bioactive nutraceutical.


Resources in this dataset:

Resource Title: Dataset 1. File Name: 41598_2017_5860_MOESM1_ESM.csvResource Description: Original file can be downloaded at https://static-content.springer.com/esm/art:10.1038/s41598-017-05860-6/MediaObjects/41598_2017_5860_MOESM1_ESM.xls

Resource Title: Dataset 1.

File Name: 41598_2017_5860_MOESM1_ESM.csv

Resource Description: Original file can be downloaded at https://static-content.springer.com/esm/art:10.1038/s41598-017-05860-6/MediaObjects/41598_2017_5860_MOESM1_ESM.xls
Original Distribution URL:  View help for Original Distribution URL https://agdatacommons.nal.usda.gov/articles/dataset/Data_from_Chondroitin_sulfate_disaccharides_modified_the_structure_and_function_of_the_murine_gut_microbiome_under_healthy_and_stressed_conditions/24662874

Scope of Project

Subject Terms:  View help for Subject Terms chondroitin sulfate; functional foods; disaccharides; bioactive compounds; intestinal microorganisms; mice; blood; exercise; short chain fatty acids; butyrates; microbial communities; Proteobacteria; inflammation; Bacteroides acidifaciens; immunomodulators; intestines; ABC transporters; carbohydrate metabolism
Collection Notes:  View help for Collection Notes DOI: 10.15482/USDA.ADC/1529209 Citation: Liu, Fang; Zhang, Na; Li, Zhaojie; Wang, Xiong; Shi, Hongjie; Xue, Changhu; Li, Robert W.; Tang, Qingjuan (2018). Data from: Chondroitin sulfate disaccharides modified the structure and function of the murine gut microbiome under healthy and stressed conditions. Springer. https://doi.org/10.15482/USDA.ADC/1529209 (Downloaded 2026-06-26)


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V1 [2026-06-27]

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