Effects of Welding Fume Exposure on Human Placental Cells

Principal Investigator(s):  View help for Principal Investigator(s) United States Department of Health and Human Services. Centers for Disease Control and Prevention. National Institute of Occupational Safety and Health

Version:  View help for Version V1

Name File Type Size Last Modified
  h98p-htn6 10/28/2025 06:31:PM

Project Citation: 

United States Department of Health and Human Services. Centers for Disease Control and Prevention. National Institute of Occupational Safety and Health. Effects of Welding Fume Exposure on Human Placental Cells. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2025-10-28. https://doi.org/10.3886/E239347V1

Project Description

Project Title:  View help for Project Title Effects of Welding Fume Exposure on Human Placental Cells
Summary:  View help for Summary
As more women join the skilled-trade workforce, the effects of workplace exposures on pregnancy need to be explored. This study aimed to identify the effects of mild-steel (MS) and stainless-steel (SS) welding fume exposures on first-trimester placental trophoblast cells, using the HTR-8/SVneo cell line. MS is primarily composed of Iron (Fe) and Manganese (Mn), while SS also contains chromium (Cr) and nickel (Ni). We found that all three welding fumes had significant effects on cellular viability, and also caused increases in free radical production, while negatively affecting their invasive capabilities. MS was the only sample to cause an increase in production of the pro-inflammatory cytokines IL-6 and IL-8. Our results show that welding fume exposure is in fact cytotoxic to trophoblasts, and understanding how these occupational exposures could impact maternal and fetal health is necessary. Identifying how the varying combinations of heavy metals and other materials present in MS and SS welding fumes, along
Original Distribution URL:  View help for Original Distribution URL https://data.cdc.gov/d/h98p-htn6

Scope of Project

Subject Terms:  View help for Subject Terms NIOSH-rescue
Collection Notes:  View help for Collection Notes Data downloaded 5/20/2025


Related Publications

Download this project

Published Versions

V1 [2025-10-28]

Export Metadata

Dublin Core

DDI 2.5

Report a Problem

Found a serious problem with the data, such as disclosure risk or copyrighted content? Let us know.

This material is distributed exactly as received from the data depositor. ICPSR has not reviewed, checked, or processed this material. For additional information about the study, please contact the investigator(s) directly. If you have questions about the accessibility of materials distributed by ICPSR or require further assistance, please visit ICPSR's Accessibility Center.