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Resolution of Pulmonary Inflammation Induced by Carbon Nanotubes and Fullerenes in Mice: Role of Macrophage Polarization

Principal Investigator(s):  View help for Principal Investigator(s) National Institute for Occupational Safety and Health

Version:  View help for Version V1

Name File Type Size Last Modified
  rd-1015-2020-0 06/23/2025 10:30:AM

Project Citation: 

National Institute for Occupational Safety and Health. Resolution of Pulmonary Inflammation Induced by Carbon Nanotubes and Fullerenes in Mice: Role of Macrophage Polarization. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2025-06-23. https://doi.org/10.3886/E233923V1

Project Description

Project Title:  View help for Project Title Resolution of Pulmonary Inflammation Induced by Carbon Nanotubes and Fullerenes in Mice: Role of Macrophage Polarization
Summary:  View help for Summary Exposure to certain engineered nanomaterials (ENMs) causes chronic lesions like lung fibrosis and cancer as a result of unresolved inflammation. Elucidating how ENM-induced inflammation is resolved is necessary for better evaluation of the fibrogenic and tumorigenic potentials of ENMs. This study aimed to identify pro-resolving mechanisms by analyzing the inflammatory and fibrogenic responses to multi-walled carbon nanotubes (MWCNTs, Mitsui-7) and fullerenes (fullerene C60, C60F) in B6C3F1 mice. The findings reveal that MWCNTs at a low dose (40 µg/mouse) and C60F at a high dose (>480 mg/mouse) stimulated acute neutrophilic inflammation, which exhibited rapid initiation and extended resolution. The lesion in MWCNT-exposed mice progressed to fibrotic granulomas by day 28 post-exposure, whereas it remained as alveolar histiocytosis in C60F-exposed mice. The ENMs induced high levels of proinflammatory lipid mediators leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) with peaks at day 1, and high levels of special

Scope of Project

Subject Terms:  View help for Subject Terms NIOSH-rescue


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Published Versions

V2 [2025-06-23]

V1 [2025-06-23]

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