Peracetic acid effects on human bronchial cells in an air liquid interface

Principal Investigator(s):  View help for Principal Investigator(s) National Institute of Occupational Safety and Health

Version:  View help for Version V1

Name File Type Size Last Modified
1 Data Set Overview - Citation.docx application/vnd.openxmlformats-officedocument.wordprocessingml.document 18.3 KB 06/23/2025 07:19:AM
3 Data Dictionary.pdf application/pdf 154.5 KB 06/23/2025 07:19:AM
Data Set Materials and Methods.pdf application/pdf 178.8 KB 06/23/2025 07:19:AM
PAA_ET1.csv text/csv 731 bytes 06/23/2025 07:19:AM
PAA_IL6.csv text/csv 766 bytes 06/23/2025 07:19:AM
PAA_IL8.csv text/csv 857 bytes 06/23/2025 07:19:AM
PAA_LDH.csv text/csv 984 bytes 06/23/2025 07:19:AM
PAA_MTT.csv text/csv 994 bytes 06/23/2025 07:19:AM
PAA_TEER.csv text/csv 883 bytes 06/23/2025 07:19:AM

Project Citation: 

National Institute of Occupational Safety and Health. Peracetic acid effects on human bronchial cells in an air liquid interface. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2025-06-23. https://doi.org/10.3886/E233924V1

Project Description

Project Title:  View help for Project Title Peracetic acid effects on human bronchial cells in an air liquid interface
Summary:  View help for Summary Peracetic acid (PAA) is utilized as an industrial disinfectant for cleaning and sterilization of water infrastructure, food-safe machinery, surgical implements, and more. PAA typically exists as a mixture with hydrogen peroxide, acetic acid, water, and oxygen. These PAA cleaning solutions have been increasingly implemented in occupational settings due to their environmentally friendly decomposition products but the strong oxidative potential that allows them to effectively sanitize surfaces also underlies their ability to damage human airways. PAA mixtures are regarded as an asthmagen and occupational exposure has been associated with acute asthma-like symptoms such as airway and mucosal irritation, cough, wheeze, and shortness of breath. To evaluate the broad effects of PAA vapor exposure to human bronchial cells in vitro, normal human bronchial epithelial (NHBE) cells were cultured at the air-liquid interface (ALI) and exposures were conducted to PAA vapors during a four-hour exposure window at four concentrations: 0, 3, 12, and 24 ppm. Cells were allowed to recover for four and twenty-four hours to capture a spectrum of post-exposure response. Data was gathered for cytotoxicity, viability, cell layer integrity (via transepithelial electrical resistance measurements and qualitative histological observations), and protein response for proinflammatory mediators Endothelin-1 (ET-1), Interleukin-6 (IL-6), and Interleukin-8 (IL-8).
Original Distribution URL:  View help for Original Distribution URL https://data.cdc.gov/National-Institute-for-Occupational-Safety-and-Hea/Peracetic-acid-effects-on-human-bronchial-cells-in/wze2-5h6n/about_data

Scope of Project

Subject Terms:  View help for Subject Terms NIOSH-rescue


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V1 [2025-06-23]

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