Applied force alters sensorineural and peripheral vascular function in an animal model of hand-arm vibration syndrome
Principal Investigator(s): View help for Principal Investigator(s) United States Department of Health and Human Services. Centers for Disease Control and Prevention. National Institute of Occupational Safety and Health
Version: View help for Version V1
| Name | File Type | Size | Last Modified |
|---|---|---|---|
| xm7q-e7uu | 06/19/2025 05:55:PM |
Project Citation:
United States Department of Health and Human Services. Centers for Disease Control and Prevention. National Institute of Occupational Safety and Health. Applied force alters sensorineural and peripheral vascular function in an animal model of hand-arm vibration syndrome. Ann Arbor, MI: Inter-university Consortium for Political and Social Research [distributor], 2025-06-19. https://doi.org/10.3886/E233580V1
Project Description
Project Title:
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Applied force alters sensorineural and peripheral vascular function in an animal model of hand-arm vibration syndrome
Summary:
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Working with vibrating hand tools is associated with the development of hand-arm vibration syndrome (HAVS). HAVS is characterized by cold-induced vasospasms, finger blanching and changes in sensory function. Vibration plays a major role in the development of the symptoms that are characteristic of HAVS, however, the hands and fingers of worker using tools are also exposed to pressure applied as the workers grip tools. The pressure applied by gripping a tool might also affect blood flow and sensorineural function. Therefore, this study examined the effects of applied pressure [2 and 4 newtons (N)] on peripheral vascular and sensorineural function using a characterized rat tail model. The tails of rats were exposed to 0, 2 or 4N of applied force for 10 days. Blood flow (laser doppler) and sensitivity of the tail to pressure (Randall-Selitto pressure test) was measured on days 1, 5 and 10 of the exposure. The sensitivity of the tail nerves to electrical stimulation was measured on days 2 and 9.
Original Distribution URL:
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https://data.cdc.gov/National-Institute-for-Occupational-Safety-and-Hea/Applied-force-alters-sensorineural-and-peripheral-/xm7q-e7uu
Scope of Project
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NIOSH-rescue
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